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2003 1
2004 2
2007 1
2009 4
2010 1
2011 1
2012 2
2013 2
2014 1
2015 2
2016 8
2017 3
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2019 1
2020 3
2021 2
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2023 3
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38 results

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Page 1
Osteocytes regulate senescence of bone and bone marrow.
Ding P, Gao C, Gao Y, Liu D, Li H, Xu J, Chen X, Huang Y, Zhang C, Zheng M, Gao J. Ding P, et al. Elife. 2022 Oct 28;11:e81480. doi: 10.7554/eLife.81480. Elife. 2022. PMID: 36305580 Free PMC article.
Together, we showed that osteocytes play critical roles in regulation of lineage cell specifications in bone and bone marrow through mediation of senescence. A hallmark of aging is the weakening of our muscles and bones, which become more fragile as we get older. These gra …
Together, we showed that osteocytes play critical roles in regulation of lineage cell specifications in bone and bone marrow through mediati …
Bone muscle crosstalk targets muscle regeneration pathway regulated by core circadian transcriptional repressors DEC1 and DEC2.
Gorski JP, Price JL. Gorski JP, et al. Bonekey Rep. 2016 Nov 16;5:850. doi: 10.1038/bonekey.2016.80. eCollection 2016. Bonekey Rep. 2016. PMID: 27867498 Free PMC article. Review.
Interestingly, the response of normal skeletal muscle to exercise and the regenerative response of skeletal muscle to the deletion of Mbtps1 in bone share some key regulatory features including a preference for slow twitch muscle fibers. ...We hope that furth …
Interestingly, the response of normal skeletal muscle to exercise and the regenerative response of skeletal muscle to the dele …
Connexin 43 Channels in Osteocytes Are Necessary for Bone Mass and Skeletal Muscle Function in Aged Male Mice.
Li G, Zhang L, Lu Z, Yang B, Yang H, Shang P, Jiang JX, Wang D, Xu H. Li G, et al. Int J Mol Sci. 2022 Nov 4;23(21):13506. doi: 10.3390/ijms232113506. Int J Mol Sci. 2022. PMID: 36362291 Free PMC article.
Osteoporosis and sarcopenia (termed "Osteosarcopenia"), the twin-aging diseases, are major contributors to reduced bone mass and muscle weakness in the elderly population. Connexin 43 (Cx43) in osteocytes has been previously reported to play vital roles in bone homeostasis …
Osteoporosis and sarcopenia (termed "Osteosarcopenia"), the twin-aging diseases, are major contributors to reduced bone mass and muscle …
The effects of hyperuricemia on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells are implicated in the elevated risk of osteopenia and vascular calcification in gout: An in vivo and in vitro analysis.
Yan B, Liu D, Zhu J, Pang X. Yan B, et al. J Cell Biochem. 2019 Dec;120(12):19660-19672. doi: 10.1002/jcb.29272. Epub 2019 Aug 12. J Cell Biochem. 2019. PMID: 31407397
Subsequently, we treated these models with allopurinol (ALLO) to study the effect of uric acid (UA) and ALLO on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells (VSMC). METHODS: Western Blot, immunohistochemistry assay, and real-time po …
Subsequently, we treated these models with allopurinol (ALLO) to study the effect of uric acid (UA) and ALLO on the differentiation and prol …
Electrical Stimulation of Denervated Rat Skeletal Muscle Ameliorates Bone Fragility and Muscle Loss in Early-Stage Disuse Musculoskeletal Atrophy.
Tamaki H, Yotani K, Ogita F, Hayao K, Nakagawa K, Sugawara K, Kirimoto H, Onishi H, Kasuga N, Yamamoto N. Tamaki H, et al. Calcif Tissue Int. 2017 Apr;100(4):420-430. doi: 10.1007/s00223-017-0250-y. Epub 2017 Feb 17. Calcif Tissue Int. 2017. PMID: 28213864
Denervated tibialis anterior (TA) muscle in the DN + ES group received ES with 16 mA at 10 Hz for 30 min/day, 6 days/week. ...These results suggest that daily ES-induced muscle contraction treatment reduced the decrease in muscle mass and cortical bone streng …
Denervated tibialis anterior (TA) muscle in the DN + ES group received ES with 16 mA at 10 Hz for 30 min/day, 6 days/week. ...These r …
Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice.
Fu X, Zhou B, Yan Q, Tao C, Qin L, Wu X, Lin S, Chen S, Lai Y, Zou X, Shao Z, Wang M, Chen D, Jin W, Song Y, Cao H, Zhang G, Xiao G. Fu X, et al. Signal Transduct Target Ther. 2020 Dec 26;5(1):297. doi: 10.1038/s41392-020-00328-y. Signal Transduct Target Ther. 2020. PMID: 33361757 Free PMC article.
Here we report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralizes the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult …
Here we report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralizes the intermittent PTH- …
Sensitive detection of Cre-mediated recombination using droplet digital PCR reveals Tg(BGLAP-Cre) and Tg(DMP1-Cre) are active in multiple non-skeletal tissues.
Dasgupta K, Lessard S, Hann S, Fowler ME, Robling AG, Warman ML. Dasgupta K, et al. Bone. 2021 Jan;142:115674. doi: 10.1016/j.bone.2020.115674. Epub 2020 Oct 6. Bone. 2021. PMID: 33031974
Assuming that Cre-activity outside of the skeletal system accounted for the difference in phenotype between Tg(BGLAP-Cre);Pik3ca(H1047R/+) and Tg(DMP1-Cre);Pik3ca(H1047R/+) mice, we developed sensitive and specific droplet digital PCR (ddPCR) assays to search for and quant …
Assuming that Cre-activity outside of the skeletal system accounted for the difference in phenotype between Tg(BGLAP-Cre);Pik3ca(H1047R/+) a …
Involvement of Dmp1 in the Precise Regulation of Hair Bundle Formation in the Developing Cochlea.
Wang Y, Lyu J, Qian X, Chen B, Sun H, Luo W, Chi F, Li H, Ren D. Wang Y, et al. Biology (Basel). 2023 Apr 20;12(4):625. doi: 10.3390/biology12040625. Biology (Basel). 2023. PMID: 37106825 Free PMC article.
Dentin matrix protein 1 (Dmp1) is a highly phosphorylated, extracellular matrix protein that is extensively expressed in bone and teeth but also found in soft tissues, including brain and muscle. However, the functions of Dmp1 in the mice cochlea are unknown. …
Dentin matrix protein 1 (Dmp1) is a highly phosphorylated, extracellular matrix protein that is extensively expressed in bone and tee …
Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age.
Gorski JP, Huffman NT, Vallejo J, Brotto L, Chittur SV, Breggia A, Stern A, Huang J, Mo C, Seidah NG, Bonewald L, Brotto M. Gorski JP, et al. J Biol Chem. 2016 Feb 26;291(9):4308-22. doi: 10.1074/jbc.M115.686626. Epub 2015 Dec 30. J Biol Chem. 2016. PMID: 26719336 Free PMC article.
Conditional deletion of Mbtps1 (cKO) protease in bone osteocytes leads to an age-related increase in mass (12%) and in contractile force (30%) in adult slow twitch soleus muscles (SOL) with no effect on fast twitch extensor digitorum longus muscles. ...Understanding …
Conditional deletion of Mbtps1 (cKO) protease in bone osteocytes leads to an age-related increase in mass (12%) and in contractile force (30 …
Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide.
Nakamura T, Honda S, Ito S, Mizoguchi T, Yamamoto T, Kasahara M, Kabe Y, Matsuo K, Suematsu M. Nakamura T, et al. J Bone Miner Metab. 2023 Jul;41(4):470-480. doi: 10.1007/s00774-023-01425-y. Epub 2023 Apr 10. J Bone Miner Metab. 2023. PMID: 37036533
Furthermore, unlike the Dmp1 knockout mice, homozygous Dmp1-T2A-Cre mice showed no skeletal abnormalities. ...Furthermore, recombination was also detected in some nuclei of skeletal muscle cells, spermatocytes, and intestinal cells. CONCLUSION: 2A-Cre functio …
Furthermore, unlike the Dmp1 knockout mice, homozygous Dmp1-T2A-Cre mice showed no skeletal abnormalities. ...Furthermore, rec …
38 results